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Hereditary Risk Form

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Disclaimer
This simple tool will assess your risk of having inherited a genetic mutation that could increase your risk of developing certain cancers. It's suitable for both men and women.

All you need is a few minutes and some information about your family history of cancer, including the age any relatives were diagnosed.

If you are unsure about your family history, we recommend you speak to your relatives to find out if anyone in your extended family has been diagnosed with cancer.

This tool doesn’t assess your risks of having inherited all possible genetic mutations. It assesses criteria relating to genetic mutations that are responsible for most popular hereditary cancers, such as BRCA1 or BRCA2 mutations and Lynch Syndrome (hereditary non-polyposis colorectal cancer includes MLH1, MSH2, MSH6, PMS2, and EPCAM). However, it also can provide you with valuable information related to other genetic mutations as well as their related cancers. If you are concerned about any other hereditary cancer in your family, please speak to your GP.

Please note: This tool is based on the information you are able to provide and how it relates to the current referral guidelines.
Acceptance of Disclaimer*
- I have read and understood the above Disclaimer.

Family testing
Has anyone in your family, either your mother or father's side, tested positive for any of the following: BRCA1 mutation; BRCA2 mutation; Lynch Syndrome (hereditary non-polyposis colorectal cancer that includes MLH1, MSH2, MSH6, PMS2, and EPCAM)?*
- Yes
- No
- Unsure

Family testing
Which is your closest relative who has tested positive for this mutation?*
- First Degree Relative (Parent, Sibling, Child)
- Second Degree Relative (Grandparents, grandchildren, Aunts, Uncles, Nephews, Nieces, Half-Siblings)
- Other

Personal history
Have you personally ever been diagnosed with cancer?*
- Yes
- No

Personal history
What type of Cancer were you diagnosed with? Please tick those that apply as a Primary Cancer (i.e. not an area of the body that another Cancer has spread to).*
- Breast - Unilateral (one breast)
- Breast - Bilateral (both breasts)
- Male Breast
- Ovarian
- Primary Peritoneal Carcinoma
- Fallopian Tube
- Prostate
- Pancreas
- Colorectal (Bowel)
- Uterine (Womb)
- Kidney
- Small Bowel (Small Intestine)
- Brain/Central Nervous System
- Stomach
- Urinary Tract (Bladder or Ureter)
- Bile Duct
- Other

Family history on your mother's side
Do you have any family history of Cancer on your mother's side? Please select the type of Cancer that applies. Please include first or second-degree relatives. First-degree relatives include parents, siblings and children. Second-degree relatives include grandparents, grandchildren, aunts, uncles, nephews, nieces and half-siblings. If you have a full sibling who has been diagnosed with cancer, please include on either your mother's or father's side, whichever makes most sense with the rest of your family history. If you have no cases of Cancer on this side of your family, please select None.*
- Breast - Unilateral (one breast)
- Breast - Bilateral (both breasts)
- Male Breast
- Ovarian
- Primary Peritoneal Carcinoma
- Fallopian Tube
- Prostate
- Pancreas
- Colorectal (Bowel)
- Uterine (Womb)
- Kidney
- Small Bowel (Small Intestine)
- Brain/Central Nervous System
- Stomach
- Urinary Tract (Bladder or Ureter)
- Bile Duct
- Other
- None

Family history on your father's side
Do you have any family history of Cancer on your father's side? Please select the type of Cancer that applies. Please include first or second-degree relatives. First-degree relatives include parents, siblings and children. Second-degree relatives include grandparents, grandchildren, aunts, uncles, nephews, nieces and half-siblings. If you have a full sibling who has been diagnosed with cancer, please include on either your mother's or father's side, whichever makes most sense with the rest of your family history. If you have no cases of Cancer on this side of your family, please select None.*
- Breast - Unilateral (one breast)
- Breast - Bilateral (both breasts)
- Male Breast
- Ovarian
- Primary Peritoneal Carcinoma
- Fallopian Tube
- Prostate
- Pancreas
- Colorectal (Bowel)
- Uterine (Womb)
- Kidney
- Small Bowel (Small Intestine)
- Brain/Central Nervous System
- Stomach
- Urinary Tract (Bladder or Ureter)
- Bile Duct
- Other
- None

Ancestry Information
Do you have any Ashkenazi Jewish ancestry?*
- Yes
- No
- Unsure

Results
You have answered that at least one of your first-degree relatives has tested positive for a genetic mutation such as BRCA1/2 or Lynch Syndrome.

This means there is a 50% chance that you will have inherited the same mutation.

This also means you are eligible for genetic testing with one of BIOPROGNOS' Hereditary Risk Solutions, such as RiskBRCA Basic, RiskBRCA Advanced, RiskGYNE, RiskCOLON, as well as RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).

Accumulated Risk throughout Life

Breast Cancer accumulated Risk throughout Life

The Breast Cancer Accumulated Risk throughout Life increases from a 12% for general population to a 46-87% when BRCA1 mutation occurs and up to 38-84% when BRCA2 mutation occurs.

General Population

BRCA1 Mutation

BRCA2 Mutation

Ovarian Cancer accumulated Risk throughout Life

The Ovarian Cancer Accumulated Risk throughout Life increases from a 1-2% for general population to a 39-63% when BRCA1 mutation occurs and up to 16-27% when BRCA2 mutation occurs.

General Population

BRCA1 Mutation

BRCA2 Mutation

Colorectal Cancer accumulated Risk throughout Life
The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 52-82% when MLH1 or MSH2 mutations occurs.

General Population

MLH1 or MSH2 Mutations

The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 22-69% when MSH6 mutation occurs.

General Population

MSH6 Mutation

The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 20% when PMS2 mutation occurs.

General Population

PMS2 Mutation

The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 52-82% when EPCAM mutation occurs.

General Population

EPCAM Mutation
You have answered that at least one of your second-degree relatives has tested positive for a genetic mutation such as BRCA1/2 or Lynch Syndrome.

This means there is a 25% chance that you will have inherited the same mutation.

This also means you are eligible for genetic testing with one of BIOPROGNOS' Hereditary Risk Solutions, such as RiskBRCA Basic, RiskBRCA Advanced, RiskGYNE, RiskCOLON, as well as RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).

Please note: If a first-degree relative of your has been tested and was not found to be carrying the mutation, it's not possible that you would have inherited the mutation. E.g. if your grandmother has a mutation, but your mother (her daughter) hasn't, then you cannot have inherited the mutation from your grandmother. This is because mutations cannot skip a generation.

Remember: Most cancers are not due to a genetic cause, but you should all be aware of the symptoms of Cancer and visit your GP if you notice anything unusual.

Accumulated Risk throughout Life

Breast Cancer accumulated Risk throughout Life

The Breast Cancer Accumulated Risk throughout Life increases from a 12% for general population to a 46-87% when BRCA1 mutation occurs and up to 38-84% when BRCA2 mutation occurs.

General Population

BRCA1 Mutation

BRCA2 Mutation

Ovarian Cancer accumulated Risk throughout Life

The Ovarian Cancer Accumulated Risk throughout Life increases from a 1-2% for general population to a 39-63% when BRCA1 mutation occurs and up to 16-27% when BRCA2 mutation occurs.

General Population

BRCA1 Mutation

BRCA2 Mutation

Colorectal Cancer accumulated Risk throughout Life
The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 52-82% when MLH1 or MSH2 mutations occurs.

General Population

MLH1 or MSH2 Mutations

The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 22-69% when MSH6 mutation occurs.

General Population

MSH6 Mutation

The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 20% when PMS2 mutation occurs.

General Population

PMS2 Mutation

The Colorectal Cancer Accumulated Risk throughout Life increases from a 2% for general population to a 52-82% when EPCAM mutation occurs.

General Population

EPCAM Mutation
Based on your answers, you may be at increased risk of having inherited a genetic mutation such as BRCA1 or BRCA2.

This means you are eligible for genetic testing with one of BIOPROGNOS' Hereditary Risk Solutions, such as RiskBRCA Basic, RiskBRCA Advanced, RiskGYNE, RiskCOLON, as well as RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).
From your answers it looks like you are unlikely to be at risk of carrying a BRCA1/2 or Lynch Syndrome gene mutation, but can check for other known gene mutations for other cancers.

In this way, you can ask for testing with RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).
From your answers it looks like you may be at risk of carrying a well-known gene mutation.

In this way, you can ask for testing with RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).
From your answers it looks like you are unlikely to be at risk of carrying a BRCA1/2 or Lynch Syndrome gene mutation and you would not meet the eligibility criteria for genetic testing.

Your risk of developing Cancer is likely to be the same as the general population. However, if in the future you find out about relatives being diagnosed with Cancer, you can use the tool again to see if it changes your risk, as well as ask for RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).

Most cancers are not due to a genetic cause, but we should all be aware of the symptoms of Cancer and visit our GP if we notice anything unusual.
From your answers it looks like someone in your family could have a genetic mutation such as BRCA1/2 or Lynch Syndrome, among others, and you did not know. That could mean you may be at risk of carrying a well-known gene mutation.

In this way, you can ask for testing with RiskGLOBAL (that captures and direct sequences all the genomic regions for 45 genes related with 15 types of Cancer, for complete study).

However, if in the future you find out about relatives being tested positive for a genetic mutation such as BRCA1/2 or Lynch Syndrome, among others, or being diagnosed with Cancer, you can use the tool again to see if it changes your risk.
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